Postdoctoral Researcher at Laboratory of Molecular Neurobiology

The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of:

Postdoctoral Researcher at Laboratory of Molecular Neurobiology

 

Number of available positions: 1

Place of work: Laboratory of Molecular Neurobiology

Researcher career profiles (R1-R4): R2/R3

Field of science: neurobiology

Type of recruitment: JPND TREMENDOS

 

Project description:

A candidate will study functions of microglia in enriched environment in the project JPND TREMENDOS: The role of microglia in the effects of environmental enrichment in neurodegenerative disorders. Environmental enrichment (EE) is an experimental paradigm that combines physical, social, and cognitive stimulation and is associated with beneficial effects in pre-clinical models of neurodegenerative disorders (NDDs). However, the molecular mechanisms underlying the advantageous effects of EE in NDDs remain largely unclear. We present here a novel hypothesis that postulates changes in microglial metabolism that affect their phagocytic and inflammatory properties to contribute towards the effects of EE in NDDs. Potential identified targets will be manipulated specifically in microglia in vitro and ex vivo to examine their distinct role in microglial phagocytosis of NDD-associated pathological aggregates. Subsequently, mice with microglia-specific manipulation of the identified target(s) will be crossed with transgenic mouse models of NDDs to study whether specific microglial pathways underlie the beneficial effects of EE in NDDs. The results of this study will advance our understanding of the role of microglia in mediating the effects of EE in NDDs and reveal mechanisms of improved modulation of microglia as novel therapeutic approaches for NDDs, including Alzheimer disease.

 

Application procedure and deadline:

Required documents:

• Copy of the PhD diploma;
• Scientific CV including personal data, education, research experience, list of publications, list of presentations and awards;
• PhD certificate;
• Contact details for former supervisors or person ready to provide references;
• Statement by the candidate that he/she will not receive remuneration from other projects funded by the National Science Centre.
• Declaration that the candidate will not take up other jobs during the period of employment in the project.

You can use the foreign equivalent of a Polish academic degree if it meets at least one of the following criteria:

• is covered by the provisions of an international agreement on the equivalence of education,
• was issued by an authorized institution operating in an EU, OECD or EFTA Member State,
• was issued in another country and recognized on the basis of the regulations on the recognition of academic degrees obtained abroad (learn more about the procedure for the recognition of academic degrees:

https://nawa.gov.pl/en/recognition/recognition-for-professional-purposes/recognition-of-scientific-degrees-and-titles

 

Applications should be sent to postdoc@nencki.edu.pl with note: “Postdoctoral Researcher JPND” with a copy to b.kaminska@nencki.edu.pl till February 28, 2025, 12:00.

For more information please contact: b.kaminska@nencki.edu.pl

Link to website: https://nencki.edu.pl/

 

Additional information:

Please include the following clause in your CV:

I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for Postdoctoral Researcher position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of 10 May 2018 (Journal of Laws of 2018, item 1000).