The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of:
Postdoctoral Researcher at Laboratory of Molecular Basis of Behavior
Number of available positions: 1
Place of work: Laboratory of Molecular Basis of Behavior
Researcher career profiles (R1-R4): R2/R3
Field of science: Neuroscience
Type of recruitment: NCN SONATA grant
Project description:
dArc Side of Amygdala: a Role of Arc in Amygdala Development and Alcohol Use Disorder
Alcohol addiction poses a significant challenge in modern society. Despite extensive research efforts, the molecular mechanisms underlying the development of alcohol dependence remain poorly understood, hindering the development of effective therapies. The activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) is pivotal in the activity of neural networks and is recognized as a master regulator of synaptic function and plasticity. However, most studies have primarily focused on Arc's function in the adult excitatory neurons of the hippocampus and cortex, leaving its role in other brain structures less explored. Using an animal model of alcohol use disorder (AUD), we have recently demonstrated that Arc levels are negatively associated with alcohol-seeking behavior regulated by Arc in the central nucleus of the amygdala. (PMID: 36357670). Moreover, we found that variations in the human ARC gene were correlated with alcohol consumption and amygdala volume. These observations suggest the causative role of Arc in both amygdala development and AUD.
In this project, we aim to elucidate the developmental role of Arc in the amygdala and its impact on the AUD phenotype using advanced methodologies such as transgenic mice, genetically modified viruses, light-sheet microscopy, and ex vivo electrophysiology. Specifically, we will investigate:
Scope of tasks:
Application procedure and deadline:
Required documents:
You can use the foreign equivalent of a Polish academic degree if it meets at least
one of the following criteria:
https://nawa.gov.pl/en/recognition/recognition-for-professional-purposes/recognition-of-scientific-degrees-and-titles
Applications should be sent to: postdoc@nencki.edu.pl, with note “Postdoctoral Researcher AS”, with a copy to a.salamian@nencki.edu.pl till July 20th, 2024.
Contact information: a.salamian@nencki.edu.pl
Link to website: www.nencki.gov.pl
https://radwanskalab.eu/
Requirements:
We are seeking a highly motivated individual with a strong background in neuroscience, particularly in the study of cellular, molecular, and behavioral mechanisms of addiction using animal models. Ideal candidates will possess the following qualifications:
Employment conditions:
Additional information:
Please include the following clause in your CV:
I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for Postdoctoral Researcher position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of 10 May 2018 (Journal of Laws of 2018, item 1000).
Information Clause:
The Controller of data is Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3.
Contact Details of the Personal Data Protection Officer: iod@nencki.edu.pl
Personal data in the recruitment form is collected and will be processed only for the purposes of recruitment for Postdoctoral Researcher position conducted by Nencki Institute of Experimental Biology PAS.
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