The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of:
Postdoctoral Researcher at Laboratory of Intracellular Ion Channels
Number of available positions: 1
Place of work: Laboratory of Intracellular Ion Channels
Researcher career profiles (R1-R4): R2/R3
Field of science: biology
Type of recruitment: OPUS-25 NCN grant
Project description:
"The Potassium Puzzle: Unraveling the Connection Between the Potassium Channel and Lipid Kinases in Kidney Functioning"
Mitochondrial potassium channels play a crucial role in maintaining cellular homeostasis and protecting against ischemia/reperfusion injury. Our recent studies have revealed that the ROMK2 isoform of the Renal Outer Medullary Potassium (ROMK) channel forms complexes with two lipid kinases: acylglycerol kinase (AGK) in mitochondria and diacylglycerol kinase ε (DGKE) in the endoplasmic reticulum (ER). These kinases catalyze the production of lysophosphatidic acid (LPA) and phosphatidic acid (PA), which stimulate ROMK2 activity. The localized synthesis of these lipids by the channel-bound kinases suggests a novel regulatory mechanism of ROMK2 in intracellular compartments. Understanding this interaction could provide new insights into renal physiology and identify potential therapeutic targets for conditions related to potassium homeostasis, electrolyte imbalances, and cytoprotection during ischemia/reperfusion events.
The primary aim of this project is to elucidate the molecular interactions between ROMK2 and the lipid kinases AGK and DGKE, and to investigate the physiological significance of these interactions in renal epithelial cells. Specific objectives include:
Scope of work:
Application procedure and deadline:
Applications should be sent to: postdoc@nencki.edu.pl, with note: „Postdoctoral Researcher PK”.
Deadline: August 18th 2024
Required documents:
You can use the foreign equivalent of a Polish academic degree if it meets at least
one of the following criteria:
https://nawa.gov.pl/en/recognition/recognition-for-professional-purposes/recognition-of-scientific-degrees-and-titles
For more information please contact: dr. hab. Piotr Koprowski
This position offers an opportunity to engage in cutting-edge research and contribute to the understanding of renal physiology and potential therapeutic strategies. Join us in this exciting endeavor to unravel the complexities of ROMK2 channel regulation and its implications for kidney function and beyond.
Additional information:
Please include the following clause in your CV:
I give consent for my personal data included in the recruitment form to be processed
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Requirements:
Employment conditions:
Information Clause:
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Contact Details of the Personal Data Protection Officer: iod@nencki.edu.pl
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