Postdoctoral Researcher

The International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, was constituted in December 2020, in partnership with University Medical Center Göttingen, Germany.
IMol has been established to conduct scientific research and provide training in the fields of biological, chemical, medical, biotechnological, bioinformatics, biophysical, pharmacological, and similar sciences, in the international environment conducive to collaborative efforts, research and development interactions with biotechnological industry, and wide dissemination of our results.
We aim at the development of solutions that will help everyone on this planet live a safer life.

Position in the project: Postdoctoral Researcher
Location: Warsaw, Poland
Scientific discipline: Structural biology, molecular biology, biochemistry
Job type (employment contract/stipend): Full-time position, fixed-term contract
Number of job offers: 1
Remuneration / stipend [amount / month]: 8 900,00 – 11 650,00 PLN gross, depending on experience
Position starts on: 1st Jul 2021
Maximum period of contract/stipend agreement: 31st Oct 2022
Institution: "ReMedy" International Research Agenda Unit, IMol PAS
Project leader: Agnieszka Chacińska and Magda Konarska, Directors of ReMedy.
Project title: “Regenerative Mechanisms for Health”
Subproject: “Bunyaviral translation strategies”
Laboratory of Structural Biology of Virus-host Interactions, Head: Piotr Gerlach, PhD
Project description: Host translation is one of the major sites of the virus-host battlefront and a center of cellular stress response pathways triggered during viral infection. The aim of this project is to investigate how segmented negative-strand RNA bunyaviruses manipulate and reprogramme cellular host translation during infection. Methodologically we plan to integrate structural biology techniques (cryo-EM, cryo-ET, and X-ray crystallography) with biochemistry and in vivo approaches. Our lab has access to state-of-the-art instrumentation, including cell culture facilities, recombinant protein purification systems, mass spectrometry, and a Glacios cryo-TEM equipped with Falcon 3EC camera. Collaborations within the Ochota Life Science campus afford access to two FIB-SEM instruments for cryo-ET sample preparation. Finally, we will have access to a Titan Krios G3i cryo-TEM equipped with both K3 and Falcon3EC cameras, located at the National Centre for Electron Cryomicroscopy in Kraków.
The successful candidate will be involved in setting up an in vivo platform – mammalian cell cultures transfected with viral mini-replicon systems, which will be exploited in functional and structural characterisation of the virus-host intracellular interactions. Experience in mammalian cell cultures, including purification of native protein complexes, is desired. Experience in cryo-EM/ET sample preparation and data processing would be an advantage.
For more information, please contact Piotr Gerlach: p.gerlach@imol.institute

Key responsibilities include:
The IMol is looking for a highly motivated person to:

• Perform experiments using biochemical, structural and molecular biology techniques (independently and in collaboration with other team members),
• Participate in experimental design and data analysis,
• Participate in the data preparation and writing of manuscripts,
• Actively participate in lab meetings, scientific seminars and conferences.

Profile of candidates/requirements:

• PhD degree in molecular biology, biophysics, biochemistry or related fields of life sciences,
• Solid knowledge and familiarity with laboratory techniques in at least one of the following disciplines: molecular biology, biochemistry, cell biology, genetics, transcriptomics,
• Very good command of English,
• Motivation and passion for experimental work.

Required documents (in English):

• Motivation letter,
• CV with the list of publications,
• Contact details of the scientific supervisor and other referee/s if available (preferably including direct supervisor of applicant’s PhD thesis).
• We offer: Work in a young, active, team in an excellent scientific environment,
• Comprehensive training in genetics, biochemistry and molecular biology,
• Access to the state-of-the-art equipment and facilities.
• Participation in courses and conferences.

Submit the following documents to: remedy@imol.institute
Please send us your application as a single pdf document. Please, use “Postdoctoral Researcher ReMedy / Bunyaviral translation strategies”as a title of your message.
We will contact selected candidates only.
You can also apply at imol.institute: https://bit.ly/3tGOfAE

To allow us to process your data, please include the following statement in your application:
“I hereby consent to have my personal data processed by The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences, with its registered office ul. Smetany 2, 00-783 Warszawa for the purpose of carrying out a recruitment process and I agree for a transfer of provided data to any entity responsible for the implementation of ReMedy project. I have been informed of my rights and duties. I understand that provision of my personal data is voluntary.”

More information on data protection and privacy policy in IMol: https://bit.ly/3sfMdXV
We will contact selected candidates only.
 

Application deadline: 25th Apr 2021
FNP programme Project is carried out within the International Research Agendas Programme of the Foundation for Polish Science