The International Institute of Molecular Mechanisms and Machines (IMol) Polish Academy of Sciences, was constituted in December 2020, in partnership with University Medical Center Göttingen, Germany.
IMol has been established to conduct scientific research and provide training in the fields of biological, chemical, medical, biotechnological, bioinformatics, biophysical, pharmacological, and similar sciences, in the international environment conducive to collaborative efforts, research and development interactions with biotechnological industry, and wide dissemination of our results.
We aim at the development of solutions that will help everyone on this planet live a safer life.
Position in the project: Postdoctoral Researcher
Location: Warsaw, Poland
Scientific discipline: Structural biology, molecular biology, biochemistry
Job type (employment contract/stipend): Full-time position, fixed-term contract
Number of job offers: 1
Remuneration / stipend [amount / month]: 8 900,00 – 11 650,00 PLN gross, depending on experience
Position starts on: 1st Jul 2021
Maximum period of contract/stipend agreement: 31st Oct 2022
Institution: "ReMedy" International Research Agenda Unit, IMol PAS
Project leader: Agnieszka Chacińska and Magda Konarska, Directors of ReMedy.
Project title: “Regenerative Mechanisms for Health”
Subproject: “Bunyaviral translation strategies”
Laboratory of Structural Biology of Virus-host Interactions, Head: Piotr Gerlach, PhD
Project description: Host translation is one of the major sites of the virus-host battlefront and a center of cellular stress response pathways triggered during viral infection. The aim of this project is to investigate how segmented negative-strand RNA bunyaviruses manipulate and reprogramme cellular host translation during infection. Methodologically we plan to integrate structural biology techniques (cryo-EM, cryo-ET, and X-ray crystallography) with biochemistry and in vivo approaches. Our lab has access to state-of-the-art instrumentation, including cell culture facilities, recombinant protein purification systems, mass spectrometry, and a Glacios cryo-TEM equipped with Falcon 3EC camera. Collaborations within the Ochota Life Science campus afford access to two FIB-SEM instruments for cryo-ET sample preparation. Finally, we will have access to a Titan Krios G3i cryo-TEM equipped with both K3 and Falcon3EC cameras, located at the National Centre for Electron Cryomicroscopy in Kraków.
The successful candidate will be involved in setting up an in vivo platform – mammalian cell cultures transfected with viral mini-replicon systems, which will be exploited in functional and structural characterisation of the virus-host intracellular interactions. Experience in mammalian cell cultures, including purification of native protein complexes, is desired. Experience in cryo-EM/ET sample preparation and data processing would be an advantage.
For more information, please contact Piotr Gerlach: email@example.com
Key responsibilities include:
The IMol is looking for a highly motivated person to:
Profile of candidates/requirements:
Required documents (in English):
Submit the following documents to: firstname.lastname@example.org
Please send us your application as a single pdf document. Please, use “Postdoctoral Researcher ReMedy / Bunyaviral translation strategies”as a title of your message.
We will contact selected candidates only.
You can also apply at imol.institute: https://bit.ly/3tGOfAE
To allow us to process your data, please include the following statement in your application:
“I hereby consent to have my personal data processed by The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences, with its registered office ul. Smetany 2, 00-783 Warszawa for the purpose of carrying out a recruitment process and I agree for a transfer of provided data to any entity responsible for the implementation of ReMedy project. I have been informed of my rights and duties. I understand that provision of my personal data is voluntary.”
We will contact selected candidates only.
Application deadline: 25th Apr 2021
FNP programme Project is carried out within the International Research Agendas Programme of the Foundation for Polish Science