The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of:
Number of available positions: 1
Place of work: the Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw
Researcher career profiles (R1-R4): R2
Field of science: biology
Type of recruitment: the EuroNanoMed III project: Reactivation of antitumor immune responses in gliomas using nanotechnology based targeted delivery
Scope of tasks:
A candidate will study “smart” nanosystems to deliver immunomodulatory agents in order to
reactivate antitumor immune responses in the brain tumor microenvironment and sensitize this tumor to immunotherapies. Innovative nanocarriers to deliver small interfering RNA (siRNA): 1) to revive cytolytic activities of NK cells, and 2) to modify tumor-associated myeloid cells by blocking their protumoral polarization and immunosuppressive functions. The nanocarriers includes liposome, polymersome and dendrimer nanoformulations functionalized with homing peptides for effective crossing of the blood-brain barrier and deliver siRNAs to the tumor, immunomodulatory activities of the cargo will be assessed ex vivo in tumor-immune cells co-cultures and in vivo in a murine model of glioblastoma. The most promising candidate nanocarriers will be tested in combination with immune checkpoint inhibitors in clinically relevant models in mice.
In this collaborative project with the University of Sapienza, CellVax, University of Marsaille and University of Tartu, we will study biodistribution and penetrance of new brain targeting nanocarriers and efficacy of gene knockdown. Immunophenotyping, bulk and scRNA-seq of immune cells from tumors and periphery will be evaluated in murine glioma models. Effective nanocarriers will be tested for antitumor activity alone and in combination with immune checkpoint inhibitors.
Application procedure and deadline:
Closing date for applications: April 30th 2021.
Applications should be sent to: email@example.com with note “postdoc BKK”.
The shortlisted candidates will be interviewed.
Please include the following clause in your CV:
“I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for assistant professor position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of 10 May 2018 (Journal of Laws of 2018, item 1000).”
The Controller of data is Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3.
Contact Details of the Personal Data Protection Officer: firstname.lastname@example.org
Personal data in the recruitment form is collected and will be processed only for the purposes of recruitment for post-doc position conducted by Nencki Institute of Experimental Biology PAS.
Giving consent for processing of your personal data is voluntary; however, it is necessary in order to take part in recruitment. I hereby state that I was informed about the right to withdraw my consent at any time. The withdrawal of the consent does not influence the lawfulness of any processing performed before the consent withdrawal.
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