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Termin ważności:
2021-03-25 - 2021-04-30
Województwo / region:

The Nencki Institute of Experimental Biology PAS is seeking a candidate for the position of:

Postdoc

Number of available positions: 1

Place of work: the Laboratory of Molecular Neurobiology, Nencki Institute of Experimental Biology PAS, Warsaw

Researcher career profiles (R1-R4): R2
Field of science: biology

Type of recruitment: the EuroNanoMed III project: Reactivation of antitumor immune responses in gliomas using nanotechnology based targeted delivery


Scope of tasks:

A candidate will study “smart” nanosystems to deliver immunomodulatory agents in order to

reactivate antitumor immune responses in the brain tumor microenvironment and sensitize this tumor to immunotherapies. Innovative nanocarriers to deliver small interfering RNA (siRNA): 1) to revive cytolytic activities of NK cells, and 2) to modify tumor-associated myeloid cells by blocking their protumoral polarization and immunosuppressive functions. The nanocarriers includes liposome, polymersome and dendrimer nanoformulations functionalized with homing peptides for effective crossing of the blood-brain barrier and deliver siRNAs to the tumor, immunomodulatory activities of the cargo will be assessed ex vivo in tumor-immune cells co-cultures and in vivo in a murine model of glioblastoma. The most promising candidate nanocarriers will be tested in combination with immune checkpoint inhibitors in clinically relevant models in mice.

 

Job description:

In this collaborative project with the University of Sapienza, CellVax, University of Marsaille and University of Tartu, we will study biodistribution and penetrance of new brain targeting nanocarriers and efficacy of gene knockdown. Immunophenotyping, bulk and scRNA-seq of immune cells from tumors and periphery will be evaluated in murine glioma models. Effective nanocarriers will be tested for antitumor activity alone and in combination with immune checkpoint inhibitors.

Oczekujemy

Requirements:

  • PhD in biology or related sciences (PhD up to 7 years before the employment),
  • documented research experience in immunology, neuroscience, veterinary, pharmacology,
  • fluent English,
  • previous training in veterinary, immunology, neurobiology, pharmacology,
  • experience with animal experimentation.

Oferujemy

Employment conditions:

  • the employment type: full time position,
  • employment period: 24 months (including 6 month probation),
  • planned start date: May 1, 2021.

 

Application procedure and deadline:

Closing date for applications: April 30th 2021.

Applications should be sent to: postdoc@nencki.edu.pl with note “postdoc BKK”.

The shortlisted candidates will be interviewed.

 

Required documents:

  • cover letter,
  • scientific CV including your personal data, education, research experience,
  • list of publications,
  • PhD certificate.

Opis firmy

Additional information:

Please include the following clause in your CV:

“I give consent for my personal data included in the recruitment form to be processed by Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3 (data controller) for the purposes of recruitment for assistant professor position pursuant to Regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC in compliance with a legal obligation to which the data controller is subject to (Art. 6 section 1 letter a) and the Act on personal data protection of 10 May 2018 (Journal of Laws of 2018, item 1000).”

Information Clause

The Controller of data is Nencki Institute of Experimental Biology PAS with its registered seat in Warsaw at Pasteur Street No. 3.

Contact Details of the Personal Data Protection Officer: iod@nencki.edu.pl

Personal data in the recruitment form is collected and will be processed only for the purposes of recruitment for post-doc position conducted by Nencki Institute of Experimental Biology PAS.

Giving consent for processing of your personal data is voluntary; however, it is necessary in order to take part in recruitment. I hereby state that I was informed about the right to withdraw my consent at any time. The withdrawal of the consent does not influence the lawfulness of any processing performed before the consent withdrawal.

Personal data collected in order to perform the recruitment process shall be processed throughout the period of time necessary for the organisation and completion of the recruitment process, as well as for considering a possible complaint; however, not longer than up to September 30th 2021.

Personal data will not be transferred to a third party.

You have the right to request the data controller for access to your personal data, to edit or limit its processing, as well as to raise an objection or transfer your data. You are also entitled to file a complaint to the supervisory body (President of the Office for Personal Data Protection).

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